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In Vitro Assays
Helping you develop and maintain effective drugs
In vitro assays are used when the particular stage of a target organism (usually a parasite or bacteria) can exist long enough outside a host to allow an assessment of its susceptibility to treatment. They are also used when a free-living stage is significant enough to merit assay.
We use in vitro assays to:
- Compare the effectiveness of a candidate compound with an existing compound
- Identify the level at which a candidate compound is effective
Although the results cannot be directly extrapolated into the final host animal, in vitro assays are a useful and cost-effective way to carry out early screening of candidate compounds.
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We can use an in vitro assay, or series of assays, to determine the level of treatment required to kill a particular parasite. We evaluate different concentrations of the treatment to establish the optimum dose.
When a parasite develops resistance to a treatment the dose response curve moves along the X-axis. We use in vitro assays to confirm the presence of and characterise this movement.